Rema Al-Wadaa1*, Darem Tabbaa2and Abdalnaser Al-Omar3
(1). Agricultural Scientific Research Center in Hama (PhD Student).
(2). Department of Public Health and Preventive Medicine, Faculty of Veterinary Medicine, University of Hama.
(3). Agricultural Scientific Research Center in Hama Research manager).
(*Correspounding Author, Rema Al-Wadaa, E-mail: rema.vet@gmail.com)
Received: 4/2/2024 Accepted: 1/4/2024
Abstract:
The research was carried out at the Hama Research Center of the General Authority for Agricultural Scientific Research for the year 2022 with the aim of studying the improvement of the L-Carnitine compound against the toxicity of the liver and kidneys resulting from the use of Formaldehyde in the male rabbits. 24 male rabbits were divided evenly into four groups as follows: The witness group is only provided by food and water. The L-Carnitine compound was given to the second group at a rate of 250 mg/kg of body weight. The third group was digested by the L-Carnitine and Formaldehyde together with milk on a daily basis by mouth with the same ratios mentioned in the second and fourth group, where the fourth group was digested with the Formaldehyde with milk at a rate of 0.1 mg/kg of animal weight per day by mouth. The experiment lasted for 90 days, during which blood was drawn from experimental animals periodically every (15) days, and liver enzymes (ALT, alanine aminotransferase, AST, aspartate aminotransferase) and kidney indicators (creatinine, CREA, urea, BUN) were measured. The results obtained showed that giving the Formaldehyde led to a high morale at the level of (5%) in the liver and kidneys indicators in the blood of rabbits male compared to the witness, while when the animals are given the L- Carnitine compound and the Formaldehyde together lowering the L- Carnitine the values of liver and kidney indicators compared to the resulting values in the form of the Formaldehyde and has become closer to the normal rate, It is concluded that the use of L-carnitine on a daily basis for male experimental rabbits plays an important role against liver and kidney toxicity resulting from formaldehyde, as it was able, due to its antioxidant and anti-inflammatory properties, to clearly reduce it, and this in turn leads to improving liver functions by lowering the level of its enzymes and reducing From the harmful effect on kidney tissue.
Keywords: Milk, Formaldehyde, L_ Carnitine, liver, kidney, Rabbit.
Full paper in Arabic: PDF