Majeed Shenawa Safih Al-Omairy1* and Sabah Muhammad Al-Haj Nasan 2
1 Department of Pathological Analysis, College of Applied Medical Sciences, Shatrah University, Shatrah, Iraq.
2 Department of Animal Production, Faculty of Agricultural Engineering, Homs University, Syria.
(*Corresponding author: Majeed Shenawa Safih Al-Omairy, Email: dr.majeed@shu.edu.ig ).
Received: 4/ 11/ 2024 Accepted: 3/ 8/ 2025
Abstract
The research reviewed the importance of genetic material (DNA) and its role in regulating vital processes and maintaining genome stability, and the factors that lead to genetic material damage, whether internal, such as oxidative stress, or external, such as harmful radiation and chemicals. The research also focused on the advanced biological mechanisms that cells use to repair DNA damage, such as base excision repair (BER) and double-strand break repair (NHEJ and HR), and the clinical and biological importance of repair mechanisms that contribute in protecting the body from genetic mutations and serious diseases such as cancer.
Keywords: genetic material damage, DNA, repair mechanisms.
Full paper in Arabic: PDF