Malaz Albasha^*(1)

(1). Science university, Department of chemistry, Aleppo university, Aleppo, Syria.

(*Corresponding author: Dr.Malaz Albasha. E-Mail: malazalbasha9@gmail.com)

Received: 5/10/2020                                   Accepted: 16/06/2021

Abstract

In this study (the research laboratories of Chemistry Departments-Aleppo University, Syria, 2018), the active components of the aerial parts of Ruta chalepensis L plant was extracted by using different solvents of methanol 70%, ethanol 80, ethyl acetate and hexane. The methanol 70% and ethanol 80% extracts of Ruta chalepensis L were produced excellent antimicrobial activities (1.5 × 10⁸ CFU/mL) against three strains of gram-positive bacteria; Bacillus substilis, Staphylococcus aureus, and Streptococcus mutans and three strains of gram-negative bacteria; Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli. And three species of fungi (2×10⁵) spores/mL; Aspergillus fumigatus, Aspergillus niger and Candida albicans. All extracts showed DPPH radical scavenging activity in a concentration–dependent manner. The extracts were used for anticoagulant assays PT and APTT assays with different concentration of the extracts. The methanol 70% and ethanol 80% extracts of Ruta chalepensis L prolonged the time taken for blood clotting in all the tested methods. The activity was increasing as the concentration of extracts increased.

Keywords: Ruta chalepensis L, antimicrobial, antifungal, antioxidant, anticoagulant, DPPH.

Full paper in Arabic: pdf