{"id":11239,"date":"2026-06-30T10:01:14","date_gmt":"2026-06-30T10:01:14","guid":{"rendered":"https:\/\/agri-research-journal.net\/SjarEn\/?p=11239"},"modified":"2026-06-30T10:01:14","modified_gmt":"2026-06-30T10:01:14","slug":"study-of-the-activity-of-the-enzymes-cpk-and-ldh-in-downer-cow-syndrome","status":"publish","type":"post","link":"https:\/\/agri-research-journal.net\/SjarEn\/?p=11239","title":{"rendered":"Study of the Activity of the Enzymes (CPK) and (LDH) in Downer Cow Syndrome"},"content":{"rendered":"

Basel Arif Alsalman1* <\/sup>and Adnan AL Dakka1<\/sup>\u00a0\u00a0\u00a0\u00a0<\/strong><\/span><\/p>\n

1 <\/sup>Department of Animal diseases\u060c Faculty of Veterinary Medicine, Hama University, Syria.<\/span><\/p>\n

(*Corresponding author: Dr. Basel Alsalman, E-Mail: baselsalmann33@gmail.com<\/a> ).<\/span><\/p>\n

Received: 29\/ 10\/ 2025\u00a0 \u00a0 Accepted: 28\/ 01\/ 2026<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

The study was conducted on 18 cows of the Friesian Holstein breed and high-yielding local dairy breeds, with an average body weight ranging between 450\u2013600 kg, and an average age between 4\u20139 years, including both pregnant and non-pregnant categories, during the period 2024\u20132025. These cows experienced prolonged primary recumbency for varying durations ranging from 24 hours to several days. They were located at the Jeb Ramleh Cattle Station affiliated with the General Organization for Cattle in Hama, in scattered farms in the Al-Ghab region, and in individually owned holdings in Hama Governorate. The cows were divided into three groups:\u00a0 1. First group (Control): Included 6 pregnant cows in advanced pregnancy (about 7\u20139 months). All were clinically healthy, based on the results of clinical examinations conducted prior to the start of the research.\u00a0 2. Second group (First experiment): Included 6 cows that experienced recumbency for varying periods ranging from 12\u201324 hours up to several days postpartum, as a result of parturient paresis. They were unable to stand after 24 hours of treatment, even after two consecutive attempts. 3. Third group (Second experiment): Included 6 cows that experienced prolonged secondary recumbency in the periparturient period, lying on the sternum or sometimes on the side after calving, for varying durations ranging from 24 hours to several days, due to musculoskeletal injuries or damage to the limbs or pelvic bones.\u00a0 The results of the study in the field of general clinical examination of the control group cows showed that body temperature, pulse rate, respiratory rate and pattern, appetite for food and water, and rumination were all within normal limits. In contrast, during the period of parturient paresis, body temperature showed a marked decrease, while heart rate was rapid. Appetite for food and water remained normal in the first experimental group, whereas all indicators were within physiological limits in the second experimental group.\u00a0 The study results indicated significant differences in blood calcium concentration in the experimental cows, as well as in the enzymatic activity values of both CPK and LDH compared to the control group. The increase in the activity of these two enzymes occurs in cases of skeletal muscle damage, where their elevated activity constitutes an important laboratory criterion for diagnosing downer cow syndrome, even during its clinical course.<\/span><\/p>\n

Keywords:<\/strong> Downer Cow Syndrome, Creatine phosphokinase, Lactate<\/span><\/p>\n

\u00a0Full paper in Arabic: PDF<\/a><\/span><\/strong><\/p>\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Basel Arif Alsalman1* and Adnan AL Dakka1\u00a0\u00a0\u00a0\u00a0 1 Department of Animal diseases\u060c Faculty of Veterinary Medicine, Hama University, Syria. (*Corresponding author: Dr. Basel Alsalman, E-Mail: baselsalmann33@gmail.com ). Received: 29\/ 10\/ 2025\u00a0 \u00a0 Accepted: 28\/ 01\/ 2026 Abstract The study was … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-11239","post","type-post","status-publish","format-standard","hentry","category-sjar"],"_links":{"self":[{"href":"https:\/\/agri-research-journal.net\/SjarEn\/index.php?rest_route=\/wp\/v2\/posts\/11239","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/agri-research-journal.net\/SjarEn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/agri-research-journal.net\/SjarEn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/agri-research-journal.net\/SjarEn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/agri-research-journal.net\/SjarEn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11239"}],"version-history":[{"count":1,"href":"https:\/\/agri-research-journal.net\/SjarEn\/index.php?rest_route=\/wp\/v2\/posts\/11239\/revisions"}],"predecessor-version":[{"id":11242,"href":"https:\/\/agri-research-journal.net\/SjarEn\/index.php?rest_route=\/wp\/v2\/posts\/11239\/revisions\/11242"}],"wp:attachment":[{"href":"https:\/\/agri-research-journal.net\/SjarEn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11239"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/agri-research-journal.net\/SjarEn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11239"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/agri-research-journal.net\/SjarEn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11239"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}